On the absolute meaning of the energy scale ~kT in the 'thermal interference' involved in enzyme coupled reactions

We propose a novel mechanism involved in enzyme-catalyzed coupled reactions in biological systems. It is assumed that an enzyme sets a constraint on the coupling ratio between the degrees of freedom coupled in the reaction. We show that this assumption leads to a mixing of free energy values between the degrees of freedom coupled in the reaction. This is an interference effect of thermal origin, which shares some properties with the quantum interference effect. We discuss the possibility that the energy scale ~kT has an absolute meaning in determining the magnitude of the thermal interference effect.